Liposomal nanoparticles for CRISPR/Cas9 delivery

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Keyword

Liposomal nanoparticles for CRISPR/Cas9 delivery

Sukurta: 21 August 2025
Kryptis: Biomokslai

Disclosed herein are lipid nanoparticles comprising one or more neutral lipid, one or more sterol, one or more cationic lipid, one or more ionizable lipid, and one or more PEG- modified lipid; in particular, the lipid nanoparticles comprising 1,2-dioleoyl-sn-glycero- 3-phosphocholine (DOPC), 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), 1,2-Dioleoyl-3-trimethylammoniumpropane (DOTAP), 6-((2-hexyldecanoyl)oxy)-N-(6- ((2-hexyldecanoyl)oxy)hexyl)-N-(4-hydroxybutyl)hexan-1 aminium (ALC-0315), and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)- 2000] (DSPE-PEG2000); compositions comprising such lipid nanoparticles, and methods of using such lipid nanoparticles and compositions.

Inventors: Rima Budvytytė, Urtė Neniškytė, Evelina Jankaitytė, Eimina Dirvelytė

Jurisdiction: EP

Link to espacenet