Methods and compositions for noninvasive prenatal diagnosis through targeted covalent labeling of genomic sites

Patents

Vilnius University researchers have been the authors of many international patents (Europe, USA, Japan and other). Inventions developed at the university are interdisciplinary so the title and descriptive keywords of the invention, patents and/or patent applications may include several research and technology fields. May you consider licensing opportunities of Vilnius university patents or patent applications, contact the Innovation Office of Science and Innovation Department (.).

Keyword

Methods and compositions for noninvasive prenatal diagnosis through targeted covalent labeling of genomic sites

Sukurta: 23 August 2023
Kryptis: Biotechnologijos

This invention relates to a method that covalently modifies unmodified and hydroxymethylated genomic sites in fetal specific genetic material present in maternal blood DNA samples and produce the adjacent genomic regions for detecting fetal aneuploidies and fetal gender using quantitative real time PCR or sequencing. A large panel of differently labeled sites and regions between maternal and fetal genetic material has been identified and they validity for diagnostic purposes of fetal trisomy of chromosome 21 has been demonstrated.

Inventors: Edita Kriukienė; Juozas Gordevičius; Milda Narmontė; Povilas Gibas

Jurisdiction: PCT

Link to espacenet