N 4-modified cytidine nucleotides and their use

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Keyword

N 4-modified cytidine nucleotides and their use

Sukurta: 04 July 2023
Kryptis: Biochemija

The present invention describes W-position modified cytidine nucleotides of formula (I). Provided herein are methods of chemical synthesis of ΛΡ-modified cytidine nucleoside triphosphates and their applications as well as uses of the cytidine analogues for the synthesis of modified nucleic acids. The nucleic acid molecule comprises DNA, RNA or a combination of DNA/RNA. One of many applications of modified cytidine nucleotides described herein is enzyme selection, when an enzyme of interest bears an activity of an esterase, amidase, oxidoreductase, lyase, ligase or other enzymatic activity, formula (I) wherein the substituants are as defined in the appended claims.

Inventors: Rolandas Meškys, Jevgenija Jakubovska; Daiva Tauraitė

Jurisdiction: LT, US, EP

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