Programmable RNA shredding by the type III-A CRISPR-Cas system of Streptococcus thermophilus (I)

Patents

Vilnius University researchers have been the authors of many international patents (Europe, USA, Japan and other). Inventions developed at the university are interdisciplinary so the title and descriptive keywords of the invention, patents and/or patent applications may include several research and technology fields. May you consider licensing opportunities of Vilnius university patents or patent applications, contact the Innovation Office of Science and Innovation Department (.).

Keyword

Programmable RNA shredding by the type III-A CRISPR-Cas system of Streptococcus thermophilus (I)

Sukurta: 03 July 2023
Kryptis: Biotechnologijos

A Type III-A CRISPR-Cas (St Csm) complex of Streptococcus thermophilus comprising crRNA, Csm4, and Csm3 and use for cleavage of RNA bearing a nucleotide sequence complementary to the crRNA, in vitro or in vivo. Methods for site-specific cleavage/shredding of a target RNA molecule using an RNA-guided RNA endonuclease comprising a minimal complex of crRNA, Csm4, and Csm3, and methods of RNA knock-down and RNA knock-out are disclosed. 999211.

Jurisdiction: EP, US

Link to espacenet.