System and method for a biomimetic fluid processing (I)

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Keyword

System and method for a biomimetic fluid processing (I)

Sukurta: 22 June 2023
Kryptis: Biotechnologijos

A system and method are provided for harvesting target biological substances. The system includes a substrate and a first and second channel formed in the substrate. The channels longitudinally extending substantially parallel to each other. A series of gaps extend from the first channel to the second channel to create a fluid communication path passing between a series of columns with the columns being longitudinally separated by a predetermined separation distance. The system also includes a first source configured to selectively introduce into the first channel a first biological composition at a first channel flow rate and a second source configured to selectively introduce into the second channel a second biological composition at a second channel flow rate. The sources are configured to create a differential between the first and second channel flow rates to generate physiological shear rates along the second channel that are bounded within a predetermined range.

Inventors: Joseph Italiano, Linas Mažutis, Jonathan Thon, David A. Weitz

Jurisdiction: EP, CN

Link to espacenet