Faculty of Chemistry

Sukurta: 27 August 2013

chf24 Naugarduko, LT-03225 Vilnius
Tel. 233 0987, fax 233 0987
E-mail:
www http://www.chf.vu.lt

Dean – Prof. Habil. Dr. Aivaras Kareiva

STAFF

45 teachers (44 holding research degree), 12 research fellows (6 holding research degree), 49 doctoral students.

RESEARCH AREAS

Synthesis and Investigation of Novel Materials and Nanostructures, Development of Analysis Methods

DOCTORAL DISSERTATIONS MAINTAINED IN 2013

I. Razmislevičienė. Dispersive liquid-liquid microextraction for the determination of metals.
A. Stirkė. Investigation of the chemical and electrical effects on saccharomyces cerevisiae yeast cell properties.
A. Voitechovičius. Synthesis and photophysical properties of non-linear arylpyrimidines.
Dr. B. Rakovska. Investigation of aniline electrochemical polymerization on different electrodes.

MAIN CONFERENCES ORGANIZED IN 2013 

18th international conference EcoBalt 2013
International conference Nanochemistry and Nanomaterials
7th International NanoSchool
Baltic Polymer Symposium 2013 

DEPARTMENT OF ANALYTICAL AND ENVIRONMENTAL CHEMISTRY

24 Naugarduko, LT-03225 Vilnius
Tel. 219 3117, 219 3114, fax  233 0987
E-mail:

Head - Prof. Dr. Stasys Tautkus 

STAFF

Professors:  Habil. Dr. A. Padarauskas, Dr. S. Tautkus, Dr. V. Vičkačkaitė, Habil. Dr. E. Juzeliunas (part-time).
Associate professors: Dr. A. Ramanavičienė, Dr. A. Kaušaitė-Minkštimienė, Dr. A. Katelnikovas, Dr. E. Naujalis (part-time).
Lecturers:  Dr. J. Kiuberis, Dr. V. Olšauskaitė.
Doctoral students: J. Baniukevič,  N. Karlonas, A. Linkevičiūtė, A. Makaravičiūtė, V. Mažeiko,  J. Rukšnaitė,  A. Stirkė,  V. Šmitienė,   L. Taujenis,  J. Voronovič.

RESEARCH INTERESTS

High-performance liquid chromatography-mass spectrometry for the investigation of polar molecules
Novel microextraction techniques for gas chromatographic analysis
Investigation of gas chromatographic analysis
Bio-, Immuno-, DNA- sensors based on nanostructured conducting polymers
Determination of trace elements using atomic absorption spectrometric, spectrophotometric and kinetic methods

RESEARCH PROJECTS CARRIED OUT IN 2013 

Projects Supported by University Budget

Chromatographic and Electromigrative Techniques: Development and Application of New Preconcentration and Separation Systems. Prof. A. Padarauskas. 2011–2015.

The performance of ultra-high pressure liquid chromatography coupled with tandem mass spectrometry in hydrophilic interaction and reversed phase separation modes was evaluated and compared for the separation of amino acids. Developed technique was applied for the monitoring of amino acids in commercial fertilizers. For the extraction of organochlorine pesticides from aqueous solutions dispersive liquid-liquid microextraction technique was suggested. The technique was applied to determine organochlorine pesticides in river water.

Main publications:

Vickackaite, V., Padarauskas, A. 2013. Ionic liquids in microextraction techniques. Central European Journal of Chemistry, Vol. 10, 652–674.

Investigation of Instrumental Methods of Analysis of Environmental, Industrial, Biological and Cultural Heritage Objects. Prof. S. Tautkus. 2011–2015.

 The methodology for determination of zinc in coffe, tea and mushrooms after extraction by a microwave system by flame atomic absorption spectrometry has been suggested. The optical materials emitting light in the orange and red range of the visible spectrum were investigated. The principle for oriented antibody immobilization on the surface (splitting of polyclonal antibody against bovine leukemia virus antigen (anti-gp51) into two half-sized fragments) was applied for the determination of bovine leukemia virus antigen (gp51) using SPR equipment.

Main publications:

Dutczak, D., Milbrat, A., Katelnikovas, A., Meijernik, A., Ronda, C. Justel, T., 2013.Yellow persistent luminescence of Sr2SiO4:Eu2+,Dy3+. Journal of Luminescence, vol. 132, 2398–2403.

German, N., Kausaite-Minkstimiene, A., Kirlyte, J., Makaraviciute, A., Ramanavicius, A., Mikoliunaite, L., Ramanaviciene, A., 2013. Determination of antibodies against human growth hormone using a direct immunoassay format and different electrochemical methods. Analyst, vol. 138, 1427–1433.

Projects, Programmes, Issues Supported by Research Council of Lithuania 

Research Council of Lithuania. Scientific project Application of micromembrane devices for the registration of specific antigen-antibody interaction. Duration: July 2013– December 2015. A. Ramanaviciene – head of the project group.

Research Council of Lithuania.Lithuania-Belarus bilateral cooperation in science and technology program, project Improved Glucose Biosensors Based on Immobilized Nanobiocomposites. Duration: January 2013–December 2014. A. Kausaite-Minkstimiene.    

The micromembrane devices for the registration of specific antigen-antibody interaction were developed and applied. Improved glucose biosensors based on immobilized nanobiocomposites were also developed.

Main publications:

Mazeiko, V., Kausaite-Minkstimiene, A., Ramanaviciene, A., Balevicius, Z., Ramanavicius, A., 2013. Gold nanoparticle and conducting Polyme-polyaniline-based nanocomposites for glucose biosensor design. Sensors and Actuators B - Chemical, vol. 189, 187–193.

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS

Institute of Chemistry (Lithuania)
Institute of Biochemistry (Lithuania)
Institute of Physics (Lithuania)
CJSC “Fermentas”, part of Thermo Fisher Scientific (Lithuania)
Namuir University (Belgium)

 OTHER SCIENTIFIC ACTIVITIES

Prof. A. Padarauskas –

  • editorial board member of the journal Chemija (Chemistry).

DEPARTMENT OF APPLIED CHEMISTRY

24 Naugarduko, LT-03225 Vilnius
Tel. 2193176, fax 233 0987
E-mail:

Head - Prof. Dr. Rimantas Raudonis

STAFF

Professors: Habil. Dr. V. Daujotis, Dr. R. Raudonis, Dr. J. Senvaitienė (part time).
Associate professors: Dr. E. Garškaitė, Dr. R. Vaitkus, Dr. S. Šakirzanovas, Dr. A. Žalga.
Lecturers: Dr. Kiuberis, Dr. D. Ragauskienė (part time), Dr. L. Riauba (part time).
Doctoral students: Y. Barushka, G. Braziulis, S. Kareiva, E. Kielė, J. Raudonienė, D. Sakalauskas, A. Zolumskis.

RESEARCH INTERESTS

Nanoparticle synthesis and film deposition for biomaterials, water cleaning, antifouling surfaces, optoelectronics

Interfacial liquid properties and development of techniques for their measurements

Solid state materials

Application of polymers for cultural heritage conservation 

RESEARCH PROJECTS CARRIED OUT IN 2013

Projects Supported by University Budget

Synthesis and Investigation of Novel Materials and Nanostructures, Development of Analysis Methods

Electrochemical Adsorption.  Prof. V. Daujotis. 2011–2015.

Drag force measurements confirm interfacial viscosity dependence on the potential obtained from piezoelectric resonator measurements but the minimum is lower. The shift in the potential of the viscosity minimum, obtained from drag force measurements, strictly follows the shift in the potential of zero charge with a change in concentration. Potential dependence of interfacial viscosity has been determined in the absence of confinement of fluid between a probe and surface.

Main publications:

Plaušinaitis, D., Pulmanas, A.. Waskaas, M., Raudonis, R., Daujotis, V., 2013. Piezoelectric resonator and drag force study of the properties of an interfacial hexafluorophosphate solution layer at gold electrode surface, Electrochimica Acta, vol. 109, 756–765.

National Research Projects

LMT project Encouragement of Students’ Scientific Activities Synthesis of Titanium Coatings and Investigations of their Properties.

Conference poster TiO2 nanostructures produced using various polymeric matrices, 18th international conference Ecobalt 2013, Vilnius, Lithuania, October 25–27, 2013.

LMT project Encouragement of Students’ Scientific Activities Synthesis of Indium-tin Oxide Nanorods and their Charachterization.

Contractual Research 

Synthesis of ITO Nanoparticles (NPs) and Nanorods (contribution: COST Project, Action MP1202 Rational design of hybrid organic-inorganic interfaces: the next step towards advanced functional materials; STSM at the Hebrew University of Jerusalem)

Research description:ITO NPs were made by combining a sol-gel method and mechanical grinding. Then, the inorganic-organic hybrid material consisting of ITO NPs and photoconductive gel of poly(4-vinyl pyridine) swollen in liquid pyridine was prepared. In the final stage an interaction between ITO NPs and photoconductive gel using conductive atomic force microscope was investigated.

Conference poster Preparation of indium-tin oxide nanoparticles and their interaction with photoconducting polymeric gel, 18th international conference Ecobalt 2013, Vilnius, Lithuania, October 25–27, 2013.

Hydroxyapaptite synthesis and surface investigations – biocompatibility applications (contribution: the National Scholarship Program of the Slovak Republic for the support of Mobility of Students, PhD Students, University Teachers, Researchers and Artist; collaboration with Slovak University of Technology in Bratislava, Faculty of Materials Science and Technology in Trnava).

Research description:Hydroxyapatite samples were made by combining a sol-gel and precipitation methods and investigated using thermal analysis and X-ray diffraction analysis techniques.

TiO2 film deposition (contribution: LamaTech project).

Paper by E. Garskaite. Preparation of hydrophilic TiO2 films by chemical solution deposition, Chemija. 

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS

Telemark University College, Porsgrunn (Norway)

DEPARTMENT OF INORGANIC CHEMISTRY

24 Naugarduko, LT-03225 Vilnius
Tel. 219 3110, fax 233 0987
E-mail:

Head – Prof. Habil. Dr. Aivaras Kareiva

STAFF

Professors: Habil. Dr. A. Abrutis, Habil. Dr. J. Barkauskas, Habil. Dr. A. Beganskienė, Habil. Dr. R. Juškėnas (part-time), Habil. Dr. A. Kareiva, Dr. A. Selskis (part-time).
Associate professors: Dr. D. Jasaitis, Dr. V. Kubilius, Dr. V. Plaušinaitienė.
Lecturer: Dr. I. Grigoravičiūtė-Puronienė (part-time).
Research fellows: Dr. I. Bogdanovičienė, Dr. Z. Šaltytė, A. Stanulis.
Doctoral students: A. Jankevičiūtė, T. Petrėnas, R. Skaudžius, J. Trinkunaite Felsen, O. Darčanova, J. Pilipavičius, E. Kielė, S. Butkutė, M. Liubinienė, M. Malakauskaitė, M. Misevičius.

RESEARCH INTERESTS

Developments of metal-organic chemical vapour deposition technique for oxide films. 
Dielectric, ferroelectric and piezoelectric materials
Magnetic and magnetoresistant materials
Transparent conducting oxides
Conservation of cultural heritage
Synthesis of metal, semiconductors and upconversion nanoparticles
New materials for conservation and preservation of cultural heritage
Synthesis and characterization of graphene and other nano-structured carbonaceous materials
Synthesis of graphene membranes
Synthesis and applications of silica nano-particles
Synthesis and characterization of inorganic-organic hybrid materials
Sol-gel synthesis and investigations of advanced nano-materials (bioceramic, optical materials)
Surfaces and interfaces 

RESEARCH PROJECTS CARRIED OUT IN 2013

Projects Supported by University Budget 

New Functional Materials and Chemical Compounds: Synthesis, Self-Order and Investigation of Properties

Synthesis of Functional Oxide Films and Heteroepitaxial Structures by MOCVD (Metalorganic Chemical Vapour Deposition).  Prof. A. Abrutis. 2011–2020.

Films of magnetoresistant LaSrMnO3, piezoelectric LiNbO3, ferroelectric PbTiO3 and high-k dielectric CeAlO3 were deposited by metal-organic chemical vapour deposition (MOCVD) technique and their properties were studied. Effect of deposition conditions on the stoichiometry and structural properties of LiNbO3 films was investigated.

Main publications:

Abrutis, A., Lukosius, M., Skapas, M., Stanionyte, S., Kubilius, V., Wenger, Ch., Zauner, A., 2013. Metal-organic chemical vapor deposition of high-k dielectric Ce-Al-O layers from various metal-organic precursors for metal-insulator-metal capacitor applications. Thin solid films, vol. 536, 68–73.

Stankevic, V., Simkevicius, C., Balevicius, S., Zurauskiene, N., Cimmperman, P., Abrutis, A., Plausinaitiene, V.,2013. Uniaxial stress influence on electrical conductivity of thin epitaxial lanthanum-strontium manganite films. Thin solid films, vol. 540, 194–201.

Synthesis and Characterization of Polycrystalline and Amorphous Materials.  Prof. A. Kareiva and Prof. J. Barkauskas. 2011–2020.

It was demostrated that nanoparticles prepared by sol-gel method were nano size and penetrated into the cellulose fibers and then attach to them. The synthesis of the lanthanide-doped nanoparticles resulted in the formation of colloidally dispersed hydrophobic particles capped with oleic acid. Preparation of graphite oxide membranes on polymer, glass and metal substrates were performed. New sol-gel method for the preparation of calcium phosphate/hydroxyapatite thin films on silicon substrate using dip-coating technique has been developed.

Main publications:

Mackevicius, M., Ivanauskas, F., Kareiva, A., Bogdanoviciene, I., 2013. Computer modeling of synthesis of calcium hydroxyapatite (CHAp).  J. Math. Chem., vol. 51, 1249–1257.

Beganskiene, A., Raudonis, R., Kareiva, A., 2013. Sol-gel preparation and characterization of novel mixed-metal cobaltates-aluminates. Chem. Engin. Commun., vol. 200, 305–315.

Projects, Programmes, Issues Supported by Lithuanian Council of Science

Transparent conducting oxide films for applications in UV and IR optoelectronics (No. MIP-023/2013). Research Council of Lithuania. Prof. A. Abrutis. 2013–2015.

Synthesis and Characterization of Nanoscaled Materials for Biotechnological and Optical Applications. Taiwan-Latvia-Lithuania Cooperation Project. Contract No. TAP-04/2011. Prof. A. Kareiva. 2011–2013.

Sol-Gel Synthesis, Characterization and Application in Odontology and Orthopedics of Calcium Nanophosphates. National Grant from Research Council of Lithuania for Posdoctoral studies. (SF-PD-2012-01-16-0294). Prof. A. Kareiva. 2012–2013.

Design of New Sol-Gel Materials for Biotechnological Applications. Lithuania-UKRAINE Cooperation Project. Prof. A. Kareiva. 2012–2013.

Technological Processes of Membranes Production for Micro-Solid Oxide Fuel Cells(MIKROKOKE-2). National Grant from Research Council of Lithuania. Prof. A. Kareiva. 2012–2014.

European Social Fund under National Integrated Programme Biotechnology and Biopharmacy (BIOTEFA). National Research Project. Funding Agency - MITA (VP1-3.1-SMM- 08-K01-005). Prof. J. Barkauskas. 2012–2015.

Cultural Heritage Restoration and Conservation Theory and Modern Technology. Lithuanian government and Ministry of Education and Science funded project for education of restorers.  Prof. A. Kareiva. 2013.

Sol-Gel Synthesis, Characterization and Application in Modern Technologies of Hybrid Organic-Inorganic Nanomaterials. National Grant from Research Council of Lithuania for Posdoctoral studies. (SF-PD-2012-12-31-0397). Prof. A. Kareiva. 2013–2014.

Preparation and Characterization of New Nanocoatings of Calcium Hydroxyapatite for Medical and Biotechnological Application. National Grant from Research Council of Lithuania for Posdoctoral studies. (SF-PD-2012-01-16-0294). Prof. A. Kareiva. 2013–2014.

Main publications:

Bartasyte, A., Plausinaitiene, V., Abrutis, A., Stanionyte, S., Margueron, S., Boulet, P., Kobata, T., Uesu, Y. Gleize, J.,2013. Identification of LiNbO3, LiNb3O8 and Li3NbO4 phases in thin films synthesized with different deposition techniques by means of XRD and Raman spectroscopy. Journal of Physics-Condensed Matter, vol. 25, Art. No 205901.

Borodavka, F., Gregora, I., Bartasyte, A., Margueron, S., Plausinaitiene, V., Abrutis, A., Hlinka, J., 2013. Ferroelectric nanodomains in epitaxial PbTiO3 films grown on SmScO3 and TbScO3 substrates. Journal of Applied Physics, vol. 113, Art. No 187216.

Margueron, S., Bartasyte, A., Plausinaitiene, V., Abrutis, A., Boulet, P., Kubilius, V., Saltyte, Z., 2013. Effect of deposition conditions on the stoichiometry and structural properties of LiNbO3 thin films deposited by MOCVD. OXIDE-BASED MATERIALS AND DEVICES IV, Editors: Teherani, FH; Look, DC; Rogers, DJ, Book Series: Proceedings of SPIE, vol. 8626, Art. No 862612.

International Science Programmes and Projects

European Network on Smart Inorganic Polymers. COST action CM1302. Prof. J. Barkauskas. 2013–2015.

Rational Design of Hybrid Organic-Inorganic Interfaces: The Next Step towards Advanced Functional Materials. COST Project (Action MP1202). Prof. A. Kareiva. 2012–2016.

Main publications: 

Jankeviciute, A., Karoly, Z., Tarakina, N. V., Szepvolgyi, J., Kareiva, A., 2013. Synthesis and characterization of spherical amorphous alumo-silicate nanoparticles using RF thermal plasma method. J. Non-Cryst. Solids, vol. 359, 9–14.

Beganskiene, A., RaudonisR., Kareiva. A., 2013. Sol-gel preparation and characterization of novel mixed-metal cobaltates-aluminates. Chem. Engin. Commun., vol. 200, 305–315.

Bogdanoviciene, I., Misevicius, M., Kareiva, A., Gross,Thomas, K. A., Yang, C.K., Pan, G.-T., Fang, H.-W., Yang,J.-C., 2013. Sol-gel synthesis and characterization of lanthanide-substituted nanostructured calcium hydroxyapatite. Adv. Sci. Technol., vol. 86, 22–27.

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS 

IHP GmbH, Frankfurt am Oder (Germany)
University Henri Poincare, Institut Jean Lamour, Vandœuvre-lès-Nancy (France)
Department of Inorganic Chemistry, Masaryk University, Brno (Czech Republic)
Department of Analytical and Inorganic Chemistry, Tallinn University of Technology (Estonia)
Department of Inorganic Chemistry, University of Tubingen (Germany)

OTHER SCIENTIFIC ACTIVITIES

Prof. A. Kareiva –

  • member of Lithuanian Academy of Sciences;
  • editorial board member of the journal Chemine Technologija (Chemical Technology);
  • deputy Editor of the journal Chemija (Chemistry);
  •  member of Council of Alytus College;
  • chairman of Chemistry Section of Lithuanian Academy of Sciences;
  • deputy Chairman of the Department of Mathematics, Physics and Chemistry of Lithuanian Academy of Sciences;
  • member of Evaluation Board of Institute of Thermal Insulation of Vilnius Gediminas Technical University;
  • member of Scientific Council of Centre for Physical Sciences and Technology;
  • The Honorary International Chair Professor at National Taipei University of Technology, Taiwan (2012–2014).

Prof. A. Beganskienė – 

  • participation and activity in International Atomic Energy Agency (IAEA) Regional Project RER/0/034 – Enhancing the Characterization, Preservation and Protection of Cultural Heritage Artefacts (2012–2013).

DEPARTMENT OF ORGANIC CHEMISTRY

24 Naugarduko, LT-03225 Vilnius
Tel. 219 3197, fax 233 0987

E-mail:

Head - Prof. Habil. Dr. Sigitas Tumkevičius

STAFF 

Professors: Habil. Dr. E. Butkus (part-time), Habil. Dr. S. Tumkevičius, Habil. Dr. P. Vainilavičius.
Associate professors: Dr. A. Brukštus, Dr. M. M. Burbulienė, Dr. I. Čikotienė, Dr. V. Jakubkienė, Dr. V. Masevičius, Dr. E. Orentas, Dr. S. Stončius, Dr. A. Žilinskas.
Lecturer: Dr. J. Dodonova.
Doctoral students: A. Bilinska, J. Bucevičius, R. Juškėnas, I. Karpavičienė, G. Petraitytė, D. Račkauskaitė, R. Rimkus, S. Višniakova.

RESEARCH INTERESTS 

Enantioselective synthesis of polycyclic molecules
Organocatalysts for asymmetric synthesis
Metal-catalyzed organic reactions
Self-assembly of organic molecules
Heterocyclic chemistry
Synthesis of supramolecular structures based on chiral bicyclic frameworks fused with heteroaromatic fragments
Design, synthesis and transformations of novel nitrogen, oxygen and/or sulphur heterocycles, their functional derivatives and structural analogs of natural compounds
Chiroptical properties
Light-emitting organic materials
Charge-transporting organic materials
Biological activity of organic compounds
Crystal engineering
X-ray diffraction
NMR, FTIR, Raman, UV, CD spectroscopy of organic compounds
Quantum chemical methods

RESEARCH PROJECTS CARRIED OUT IN 2013

Projects Supported by University Budget

Design and Synthesis of New Organic Materials, Investigation of their Properties and Self-Assembling, Application in Optoelectronics and Biochemistry. Prof. E. Butkus, Prof. S. Tumkevičius. 2009–2013.

Pyrrolopyrimidine derivatives possessing different sterically-hindered end-groups were synthesized and formation of the water-stable fluorescent organic nanoparticles was demonstrated. Two groups of benzenesulfonamide derivatives, bearing pyrimidine moieties, were designed and synthesized as inhibitors of carbonic anhydrases (CA). A facile, one-pot and good-yielding synthetic method for the preparation of 4,6- and 2,4-pyrimidinediamines was developed.

Main publications:

Skardžiūtė, L., Kazlauskas, K., Dodonova, J., Bucevičius, J., Tumkevičius, S., Juršėnas, S., 2013. Optical Study of the Formation of Pyrrolo[2,3-d]pyrimidine-based Fluorescent Nanoaggregates. Tetrahedron, vol. 69, 9566–9572.

Capkauskaite, E., Zubriene,  A., Smirnov,  A., Torresan,  J., Kisonaite,  M., Kazokaite,  J., Gylyte,  J., Michailoviene,  V., Jogaite,  V., Manakova,  E., Grazulis,  S., Tumkevicius,  S., Matulis.,  D. 2013. Benzenesulfonamides with pyrimidine moiety as inhibitors of human carbonic anhydrases I, II, VI, VII, XII, and XII. Bioorg. Med. Chem., vol. 21 (22), 6937–6947.  

Jakubkiene, V., Zurba, J., Cikotiene, I., 2013. N-nitroso group-assisted nucleophilic aromatic substitution of 6-chloropyrimidines: a facile and efficient synthesis of pyrimidine-4,6- and 2,4-diamines.  Synthesis, vol. 45, iss. 4, 448–451.

National Research Projects 

Research Council of Lithuania. An Integrated Discovery of Novel Anti-Cancer Compounds: From Fundamental Researches to Purposeful Modeling and Synthesis. Global Grant Project No. VP1-3.1-ŠMM-07-K-01-002. Research Leader: Assoc. Prof. I. Čikotienė. 2011–2015.

A series of α-branched α,β-unsaturated ketones were prepared in a straightforward manner by the acid catalyzed coupling between arylalkynes and carbaldehydes. The compounds were active against the resistant cancer cells T-47D. The resulting lead showed GI50 values in the range 0.32‑0.53 µM against all cell lines tested. It was found that an N-nitroso moiety can be used for activation of chloropyrimidines towards nucleophilic substitution reaction with amines.

Main publications:

Karpaviciene, I., Cikotiene, I., Padron, J. M., 2013. Synthesis and antiproliferative activity of α-branched α,β-unsaturated ketones, Eur. J. Med. Chem., vol. 70, 568–578.

Cikotiene, I., Jonusis, M., Jakubkiene, V., 2013. The first example of the Fischer–Hepp type rearrangement in pyrimidines, Beilstein J. Org. Chem., vol. 9, 1819–1825.

Karpaviciene, I., Cikotiene, I., Uniqu, A., 2013. Cascade Reaction between 3-Arylprop-2-inylcarboxylates and Benzaldehydes Leading to the Formation of Morita–Baylis–Hillman Adducts, Org. Lett., vol. 15 (1), 224–227.

Research Council of Lithuania. Synthesis of Chiral Synthons and Application in Supramolecular Chemistry and Organocatalysis.Global Grant Project No. VP1-3.1-šmm-07-k-01-030. Research Leader: Dr. S. Stončius. 2011–2015.

The synthesis of the enantiomerically pure N-Boc 9-azabicyclo[3.3.1]nonane-2,6-dione was accomplished from the corresponding diols; the latter were obtained in an enantiopure form via resolution of their diastereomeric esters or by using Candida rugosa lipase. Novel C2-symmetric bicyclo[3.3.1]nona-3,7-diene-2,6-diol derivatives were found to be efficient ligands for rhodium-catalyzed asymmetric addition of arylboronic acids to cyclohexenone, furnishing 3-arylcyclohexanones in excellent yields and enantioselectivity up to 96% ee.

Main publications:

Bieliūnas, V., Račkauskaitė, D., Orentas, E., Stončius, S., 2013. Synthesis, Enantiomer Separation and Absolute Configuration of 2,6-Oxygenated 9-Azabicyclo[3.3.1]nonanes. J. Org. Chem., vol. 78, 5339–5348.

Research Council of Lithuania.Double Channel Photosystem Based on Tubular Supramolecular Polymers. Global Grant Project No. VP1-3.1-ŠMM-07-K-03-007. Research Leader: Assoc. Prof. E. Orentas. 2013–2015.

Synthesis, solvent-, and guest-controlled self-assembly, and self-sorting of new hydrogen-bonded chiral cavity based on the 4H-bonding ureidopyrimidinone motif fused with the bicylo[3.3.1]nonane framework has been investigated. The host guest interaction of unconventional pi-acidic supramolecular receptors for fullerenes is turned off and on by changing the solvent, whereas the selection of size and the very composition of the cavity aggregate are controlled by either the change of solvent or the addition of fullerene guest, making the systems a new type of self-sorting device.

Main publications:

Shi, QX., Bergquist, K.-E., Huo, R., Li, J., Lund, M., Vacha, R., Sundin, A., Butkus, E., Orentas, E., Warnmark,  K., 2013. Composition- and Size-Controlled Cyclic Self-Assembly by Solvent- and C-60-Responsive Self-Sorting. J. Am. Chem. Soc., vol. 135(40), 15263–15268.

Research Council of Lithuania. Molecular Tools for Epigenomics and Rnomics. Global Grant Project No. VP1-3.1-ŠMM-07-K-01-105. Assoc. Prof. V. Masevičius (research promoter). 2011–2015.

The designed hex-2-ynyl moiety-based cofactor analogues with terminal amino, azide, or alkyne groups showed a markedly improved enzymatic transalkylation activity and proved well suitable for methyltransferase-directed sequence-specific labeling of DNA in vitro and in bacterial cell lysates. Furthermore, deposition of alkyne and azide groups onto DNA in combination with bioortogonal click labeling paves the way to specific in vivo labeling of these biologically important macromolecules.

Main publications:

Lukinavičius, G., Tomkuvienė, M., Masevičius, V., Klimašauskas, S., 2013.Enhanced chemical stability of AdoMet analogues for improved methyltransferase-directed labeling of DNA. ACS Chem. Biol., vol. 8, 1134–1139.

Research Council of Lithuania. High-Tech Materials Development Research and Application (No. VP1-3.1-ŠMM-08-K-01-014). Research leaders of Project group: Prof. E. Butkus, Assoc. Prof. V. Masevičius. 2012–2014.

A new protocol was developed for the synthesis of 2,3-dihydroimidazo[1,2-c]pyrimidines, based on an intramolecular reaction between pyrimidine nitrogen atom and an acetal moiety in the presence of boron trifluoride etherate. The method was expanded to permit the synthesis of the triheterocyclic imidazo[1,2-c]pyrazolo[4,3-e]pyrimidine system.

Main publications:

Juškėnas, R., Masevičius, V., Tumkevicius, S., 2013.Reactivity of Pyrimidine Nitrogen Atom toward an Acetal Moiety: Formation of 3-Ethoxy-2,3-dihydroimidazo[1,2-c]pyrimidines by Intramolecular Cyclization of N-4-(2,2-Diethoxyethyl) pyrimidine-4-amines. Synthesis, vol. 45, 2438–2446.

Research Council of Lithuania. Design of Perspective Materials for Application as Semiconductors and in Nano-Technologies and their Characterization by Methods of Steady State and Ultrafast Spectroscopy in a Wide Spectral Range. (No. VP1-3.1-ŠMM-08-K-01-004/KS-120000-1756). Research leader of the Project group: Prof. Sigitas Tumkevičius. 2012–2014.

An efficient highly site-selective synthesis of 2,4,7-triarylpyrrolo[2,3-d]pyrimidines from 4-chloro-2-methylthiopyrrolo[2,3-d]pyrimidine was developed. The proposed synthetic pathway is based on three sequential arylation reactions: the Suzuki coupling at position 4 of pyrrolo[2,3-d]pyrimidine, Cu(I) catalyzed N(7)-arylation and Ni(0)-catalyzed desulfitative reaction of 2-methylthio group with aryl Grignard reagents.

Main publications:

Urbonas, R.V., Poskus, V., Bucevicius, J., Dodonova, J., Tumkevicius S., 2013. A Novel Highly Site-Selective Synthesis of 2,4,7-Triarylpyrrolo[2,3-d]-pyrimidines by a Combination of Palladium(0)-, Nickel(0)-, and Copper(I)-Catalyzed Cross-Coupling Reactions. Synlett, vol. 24, 1383–1386.

Research Council of Lithuania. Novel Functional Pyrrolopyrimidines: Synthesis and Photophysical Properties. (MIP-027/2013). Research leader: Prof. S. Tumkevicius. 2013–2015. 

The project is targeted at designing and thorough investigation of novel pyrrolo[2,3-d]pyrimidine-based materials featuring extended pi-conjugated electron system and efficient light-emission properties for optoelectronic, biochemical and/or biomedical applications. To improve a conjugation in pi-systems pyrrolo[2,3-d]pyrimidine derivatives with a 1,2,3-triazolyl linker between the pyrrolopyrimidine and aromatic parts of molecules have been synthesized and evaluated for their fluorescent properties.

International Research Projects 

Bilateral cooperation in scientific research and experimental development in Lithuanian and French integrated action program “Gilibert” project Cyclodextrins – Supramolecular Organocatalysts for the Synthesis of Substituted Pyrrolo and Pyrazolopyrimidines by Multicomponent Reactions (No. TAP-LZ-08/2013). Research leader: Prof. S. Tumkevicius. 2013-2014. 

Synthesisi of some modified cyclodextrins has been carried out and their catalytic ability in the synthesis of pyrimidine and pyrrole derivatives has been investigated. It has been shown that employing cyclodextrins as catalysts in the Biginelli and Paal-Knorr reactions improves the yields of target pyrimidines and pyrroles, respectively. 

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS

Center for Physical Sciences and Technology (Lithuania)
Lund University (Sweden)

La Laguna University (Spain)

Jyvaskyla University (Finland)

d’Artois University (France)

OTHER SCIENTIFIC ACTIVITIES

Prof. E. Butkus –

  • editorial board member of the journal Chemija (Chemistry), http://www.lmaleidykla.lt/publ/0235-7216/2013/3/TitulinisRedkolegija.pdf;
  • member of the EU program committee of the FP7 Ideas program;
  • member of the Lithuanian Academy of Sciences;
  • member of the organising committee of the international conference onorganic synthesis Balticum Organicum Syntheticum 2014;
  • Chairman of the Scientific committee and Organizing committee of the international;
  • editorial board member of the journal Chemija (Chemistry);
  • member of the Organizing committee of the international conference Baltic Polymer Symposium 2013;
  • secretary of the Organizing committee of the international conference Baltic Polymer Symposium 2013.

Prof. S. Tumkevičius -

DEPARTMENT OF PHYSICAL CHEMISTRY

24 Naugarduko, LT-03225 Vilnius
Tel. 233 7517, 219 3114, fax 233 0987
E-mail:

Head - Prof. Habil. Dr. Arūnas Ramanavičius

STAFF 

Professors: Habil. Dr. A. Ramanavičius, Dr. H. Cesiulis, Habil. Dr. A. Malinauskas (part-time), Habil. Dr. R. Ramanauskas (part-time).
Associate professors: Dr. A. Valiunienė, Dr. D. Plausinaitis, Dr. R. Valiūnas (part-time).
Lecturers: Dr. Z. Margaian.
Doctoral students: I. Balevičiūtė, I. Vilkončienė, A. Alubeckas, U. Samukaitė-Bubniennė, L. Mikoliūnaitė, L. Dėdilaitė.

RESEARCH INTERESTS 

Bio-, Immuno-, DNA- sensors based on nanostructured conducting polymers
Corrosion, Metal alloys, Electrochemical Impedance spectroscopy, Deposition of Silver-based coatings

RESEARCH PROJECTS CARRIED OUT IN 2013 

Projects Supported by University Budget

New Functional Materials and Chemical Compounds: Synthesis, Self-Order and Investigation of Properties.

Development of Electroanalytical Systems. Prof. A. Ramanavičius. 2011–2015.

Investigation of the Interfacial Processes. Prof. H. Cesiulis. 2011–2015.

New sensing platform based on modified glassy carbon (GC) suitable for design of heavy metal-ion sensor is reported. The applicability of poly-5NP- and poly-5A6NPfunctionalized carbon surfaces for the determination of Cu(II) ions was demonstrated by formation of complexes between GC-grafted poly-5NP and poly-5A6NP layers and Cu(II) ions.Nanocrystalline Co-W coatings with 13–36 at.% W were obtained from citrate-borate electrolyte under DC and PC plating conditions.

Main publications:

Mazeiko, V., Kausaite-Minkstimiene, A., Ramanaviciene, A., Balevicius, Z., Ramanavicius, A., 2013. Gold Nanoparticle and Conducting Polymer – Polyaniline – Based Nanocomposites for Glucose Biosensor Design. Sensors and Actuators B-Cemical, vol.189, 187–193. DOI.org/10.1016/j.snb. 2013.03.140.

Baniukevic, J., Kirlyte, J., Ramanavicius, A., Ramanaviciene A., 2013.Application of oriented and random antibody immobilization methods in immunosensor design.Sensors and Actuators B-Cemical, vol.189, 217–223. DOI:10.1016/j.snb. 2013.03.126.

Baleviciute, I., Balevicius, Z., Makaraviciute, A., Ramanaviciene, A., Ramanavicius A., 2013.Study of Antibody/Antigen Binding Kinetics by Total Internal Reflection Ellipsommetry. Biosensors and Bioelectronics, vol. 39, 170–176. DOI:10.1016/j.bios. 2012.07.017.

National Research Projects

European Social Fund Agency: Materials for High Technologies (Nr. VP1-3.1-ŠMM-08-K-01-014). (Together with the Department of Organic Chemistry and Department of Polymer Chemistry). 

Titanium treatment methods for the obtaining of ordered nanoporous arrays. The novel electropolishing of Ti procedure has been developed. The perspective alloys and metals for the filling nanoporous have been chosen.

Main publications:

Ratautaite, V., Ramanaviciene, A., Oztekin,Y., Voronovic, J., Balevicius, Z., Mikoliunaite, L., Ramanavicius, A., 2013.Electrochemical Stability and Repulsion of Polypyrrole FilmColloids and Surfaces A. Physicochemical and Engineering Aspects, vol. 418, 16–21. DOI:10.1016/j.colsurfa. 2012.10.052.

Baniukevic,J., Boyaci, I.H., Bozkurt, A.G., Tamer, U., Ramanavicius, A., Ramanaviciene, A., 2013. Magnetic gold nanoparticles in SERS-based sandwich immunoassay for antigen detection by well oriented antibodies. Biosensors and Bioelectronics, vol. 43, 281–288. DOI: 10.1016/j.bios. 2012.12.014.

German, N., Kausaite-Minkstimiene, A., Kirlyte, J., Makaraviciute, A., Ramanavicius, A., Mikoliunaite, L., Ramanaviciene, A., 2013. Determination of antibodies against human growth hormone using direct immunoassay format and different electrochemical methods. Analyst , vol. 138, 1427–1433. DOI:10.1039/C2AN36682G. 

International Research Projects

COST Action CM1101: Colloidal Aspects of Nanoscience for Innovative Processes and Materials. 

Development of enzymatic biosensors, LMT, TAP LB-09/2013 project.

FP7 programme: FP7-PEOPLE-2009-IRSES: Template-assisted deposition of functional materials and devices (PIRSES-GA-2009-247659).

The electrodeposition of Fe–Co–W alloys was examined. Regardless of the electrolyte temperature or rotation rate, the addition of Fe ions into the electrolyte inhibited the Co partial current density, and thus the Co content into the deposit, attributed to an anomalous codeposition behaviour.

Main publications:

Vaitkuviene, A., Kaseta, V.,Voronovic, J.,  Ramanauskaite, G., Biziuleviciene, G., Ramanaviciene, A., Ramanavicius, A., 2013.  Evaluation of Cytotoxicity of Polypyrrole Nanoparticles Synthesized by Oxidative Polymerization. Hazardous materials, vol. 250–251, 167–174. DOI:10.1016/j.jhazmat.2013.01.038.

Balevicius, Z., Makaraviciute, A., Babonas, G.J., Tumenas, S., Bukauskas, V., Ramanaviciene, A., Ramanavicius, A., 2013. Study of optical anisotropy in thin molecular layers by total internal reflection ellipsometry. Sensors and Actuators B-Cemical, vol. 181, 119–124. DOI: 10.1016/j.snb.2013.01.059.

Ratautaite, V., Topkaya, S.N., Mikoliunaite, L., Ozsoz, M., Oztekin, Y., Ramanaviciene, A., Ramanavicius, A., 2013. Molecularly Imprinted Polypyrrole for DNA Determination. Electroanalysis, vol. 25, 1169–1177.  DOI:10.1002/elan.201300063.

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS 

Namuir University (Belgium)
Hasselt University (Belgium)
Katholieke University Leuven (Belgium)
Northeastern University Boston (US)
Institute of Applied Physics of NAS Moldova

OTHER SCIENTIFIC ACTIVITIES

Prof. A. Ramanavičius–

Prof. H. Cesiulis –

  • member of Scientific Committee for international conference Balttrib 2013, Kaunas (Lithuania).

DEPARTMENT OF POLYMER CHEMISTRY

24 Naugarduko, LT-03225 Vilnius
Tel. 219 3113, 219 3227, fax 233 0987
E-mail:

Head - Prof. Dr. Ričardas Makuška

STAFF

Professors: Dr. R. Makuška, Dr. S. Budrienė.
Associate professor: Dr. A. Vareikis.
Lecturer: Dr. T. Kochanė.
Research fellows: Dr. V. Pamedytytė, A. Strakšys.
Doctoral students: Č. Višnevskij, A. Bočkuvienė, J. Jonikaitė-Švėgždienė, G. Čiuta, S. Mačiulytė, V. Klimkevičius.

RESEARCH INTERESTS

Synthesis and modification of polymers
Living radical polymerization
Polyelectrolytes from natural and synthetic building blocks
Amphiphilic and charge-carrying brush polymers
Cationic polymers for gene transfection
Polymeric carriers for bioactive compounds
Immobilization of biocatalysts onto polymeric carriers
Encapsulation of hydrophilic and lipophilic materials within polymeric shells

RESEARCH PROJECTS CARRIED OUT IN 2013 

Projects Supported by University Budget

Synthesis and Study of Hydrophilic Polymers for Bio- and Nanotechnologies. Prof. R. Makuška. 2011–2015.

Polymerization by ISARA ATRP of methacrylic acid neutralized by simple amines was studied enabling to synthesize cylindrical brush polymers carrying negatively-charged side chains. Microparticles of poly(urethane-urea) were obtained from poly(vinyl alcohol) and 4,4’-methylene dicyclohexyl diisocyanate via polyaddition reaction. Properties of the synthesized polyurethanes and their application for immobilization of maltogenase were investigated.

Main publications:

Liu, X., Thormann E., Dedinaite, A., Rutland, M., Visnevskij, C., Makuska, R., Claesson, P.M., 2013. Low friction and high bearing capacity layers formed by cationic-block-non-ionic bottle-brush copolymers in aqueous media. Soft Matter, vol. 9 (22), 5361–5371.

Meizeraityte, M., Gruskiene, R., Makuska, R., Dienys. G., 2013. Modified chitosan as a spacer for protein immobilization. Biocatalysis and Biotransformation, vol. 31 (4), 181–189.

National Research Projects

Research Council of Lithuania. Polymeric Anionic Bottle-Brush Structures as Mimics for Biolubricants (No MIP-051/2012). Prof. R. Makuška. 2012–2014.

New technique for living radical polymerization of hydrophilic and charge-containing monomers in aqueous solutions ISARA ATRP was developed and tested. Linear oligomeric RAFT chain transfer agents with multiple trithiogroup were synthesized which were used for the synthesis of multiblock polymeric structures containing brush fragments. Anionic brush polymers and triblock copolymers with central anionic brush block were studied by DLS, DSC and TGA.

Main publications:

Visnevskij, C., Makuska, R., 2013. SARA ATRP in aqueous solutions containing supplemental redox intermediate: controlled polymerization of [2-(methacryloyloxy)ethyl] trimethylammonium chloride. Macromolecules, vol. 46, 4764–4771.

Gromadzki, D., Stepanek, P., Makuska. R., 2013. Synthesis of densely grafted copolymers with tert-butyl methacrylate / 2-(dimethylamino ethyl) methacrylate side chains as precursors for brush polyelectrolytes and polyampholytes. Materials Chemistry and Physics, vol. 137 (3), 709–715.

European Social Fund under National Integrated Programme Biotechnology and Biopharmacy. Grant VP1-3.1-SMM-08-K01-005.

Synthesis and Investigation of the Possibility of Applying of Organic and Inorganic Carriers and Matrices for Suitable Selected Biocatalyzators. Prof. S. Budrienė. 2012–2015.

Poly(urethane-urea) was synthesized from poly(vinyl alcohol) and isophorone diisocyanate, and its microparticles were obtained by modification with ethylenediamine and glutaraldehyde. Polymeric carriers were used for immobilization of urease.

Main publications:

Razumiene, J., Sakinyte, I., Kochane, T., Maciulyte, S., Straksys, A., Budriene, S., Barkauskas, J., 2013. Carbon Electrode based Urea Sensor Modification of Graphite and New Polymeric Carriers for Enzyme Immobilization. BIODEVICES 2013 – International Conference on Biomedical Electronics and Devices, 197–201.

Strakšys, A., Kochanė, T., Budrienė.S., 2013. Synthesis and characterization of poly(urethane-urea)microparticles from poly(vinyl alcohol) and binary blends of diisocyanates and their application for immobilization of maltogenic α-amylase. Chemija, vol. 24 (2), 160–169.

MAIN R&D&I (RESEARCH, DEVELOPMENT AND INNOVATION) PARTNERS

Thermo Fisher Scientific Baltics (Lithuania)
Institute of Biochemistry, Vilnius University (Lithuania)
Royal Institute of Technology (Sweden)
Swiss Federal Laboratories for Material Science and Technology (Switzerland)

OTHER SCIENTIFIC ACTIVITIES

Prof. R. Makuška –

  • Chairman of the Scientific committee and Organizing committee of the international conference Baltic Polymer Symposium 2013;
  • editorial board member of the journal Chemija (Chemistry).

Prof. S. Budrienė –

  • member of the Organizing committee of the international conference Baltic Polymer Symposium 2013.

Dr. T. Kochane –

  • secretary of the Organizing committee of the international conference Baltic Polymer Symposium 2013.